In a recent study, the effect of probiotic supplementation on plasma metabolite profile was investigated in a group of patients who had undergone Roux-Y gastric bypass surgery. The study was a prospective, randomized, double-blind, placebo-controlled clinical trial. The patients were randomly assigned to receive either a probiotic supplement or a placebo for eight weeks. The probiotic supplement contained Lactobacillus rhamnosus and Lactobacillus helveticus.

The results of the study showed that the probiotic supplementation had a significant effect on the plasma metabolite profile of the patients. The patients who received the probiotic supplement had a significantly lower level of plasma glucose and a significantly higher level of plasma short-chain fatty acids than the patients who received the placebo. The probiotic supplementation also had a significant effect on the gut microbiota of the patients. The patients who received the probiotic supplement had a significantly higher level of Lactobacillus species in their gut microbiota than the patients who received the placebo.

The results of this study suggest that probiotic supplementation may be a useful adjuvant therapy for patients who have undergone Roux-Y gastric bypass surgery. Probiotic supplementation may help to improve the plasma metabolite profile and the gut microbiota of these patients.