Randomised controlled trials (RCTs) are an important tool for evaluating the effectiveness of interventions in healthcare. A recent RCT conducted at a breast cancer family history clinic in the UK has compared the effectiveness of two different interventions for preventing multiple diseases and promoting in women attending the clinic.

The study included a total of 200 women aged between 18 and 70 years old. Half of the participants were randomly assigned to receive a weight loss programme, while the other half received written advice on healthy lifestyle changes. The weight loss programme consisted of weekly group sessions for 12 weeks, which focused on diet, physical activity, and behaviour change. The written advice included information on healthy eating, physical activity, and lifestyle changes.

At the end of the 12-week period, the researchers found that the women who had received the weight loss programme had significantly greater reductions in body mass index () and waist circumference than those who had received the written advice. Furthermore, the women in the weight loss programme group also had significantly greater reductions in blood pressure, cholesterol, and triglyceride levels than those in the written advice group.

The results of this RCT suggest that weight loss programmes are more effective than written advice for promoting multiple disease prevention and weight loss in women attending a breast cancer family history clinic. This is an important finding, as it suggests that weight loss programmes may be a useful tool for helping to reduce the risk of multiple diseases in women with a family history of breast cancer.

The findings of this study should be interpreted with caution, however, as the sample size was relatively small and the study was conducted in a single clinic. Further research is needed to confirm the findings of this study and to determine the long-term effectiveness of weight loss programmes for preventing multiple diseases in women with a family history of breast cancer.